Lab Introduction & Major Research Interests
As a clinical scientist whose major covers both basic and clinical aspects, my research interests are diverse and I am particularly enthusiastic for any innovative breakthrough into the field of pain medicine and anesthesia:
1. Pain medicine in basic sciences:
elucidating the mechanism of acupuncture, neonatal pain, opioid-induced immunosuppression, glia-cell derived nociception/analgesia, animal ethics in pain research by:
– behavior
– pharmacology
– immunohistochemistry
– functional imaging technology
2. Pain medicine in clinical sciences:
designing and conducting the randomized-controlled study for efficacy and side effect of various analgesics (opioid agonist-antagonist, neurotoxin) with specific aim at reduction of pain and pain-related comorbidity:
– neuropathic pain, fibromyalgia
– post-operative pain
– cancer pain
3. Clinical anesthesia:
designing device for airway and infusion pump
4. Complementary and integrative medicine
designing and conducting clinical trial associated with:
– taichi chuan’s effect on asthma, hemodialysis
– acupuncture’s effect on migraine headache and cerebral microcirculation
Recent Representative Publication ( * corresponding author)
1. Chih-Peng Lin, and Wei-Zen Sun* et al.: CXCL12/CXCR4 Signaling Contributes to the Pathogenesis of Opioid Tolerance: A Translational Study. Anesth Analg, 124(3):972-979, 2017.
2. Yu-Chang Yeh, and Wei-Zen Sun*, et al.: Effect of Dexmedetomidine on Intestinal Microcirculation and Intestinal Epithelial Barrier in Endotoxemic Rats. Anesthesiology, 125(2):355-67, 2016.
3. Chih-Peng Lin, and Wei-Zen Sun* et al.: The role of spinal CXCL1 (GROα) in opioid tolerance- a human-to-rodent translational study, Anesthesiology, 122(3), 666-76, 2015.
4. Jaung-Geng Lin, and Wei-Zen Sun* et al.: The effect of high and low frequency acupuncture in pain after lower abdominal surgery. Pain, 99(3): 509-14, 2002.