Lab Introduction & Major Research Interests
I have been a Professor and Yushan Fellow at NTU since August 2021, following 15 years on the faculty at the University of Oxford (where I am currently a Visiting Professor). My research is focused on the computational modelling of cerebral blood flow and metabolism. I am interested in studying how the brain is supplied with nutrients and how this supply is maintained in both health and disease (e.g., ischaemic stroke). Using computational models, hypotheses can be tested, and treatments simulated to model outcome. Most recently, I have started to develop models that simulate longer time scales, with a view to modelling brain health over periods of years and decades, including the effects of ageing, hypertension, exercise, and sleep; the aim here is to understand better how these interventions affect long-term brain health. I am interested in developing new collaborations with any researchers interested in how these interventions have a quantitative effect on the brain, both in the short-term and the long-term.
Recent Representative Publication ( * corresponding author)
1. Tong Z, Catherall M, Payne SJ. A multiscale model of cerebral autoregulation. Med Eng Phys. 2021 Sep;95:51-63. doi: 10.1016/j.medengphy.2021.08.003.
2. Chen X, Józsa TI, Payne SJ. Computational modelling of cerebral oedema and osmotherapy following ischaemic stroke. Comput Biol Med. 2022 Dec;151(Pt A):106226. doi: 10.1016/j.compbiomed.2022.106226. Epub 2022 Oct 20.
3. Xue Y, Georgakopoulou T, van der Wijk AE, Józsa TI, van Bavel E, Payne SJ. Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees. PLoS Comput Biol. 2022 Aug 5;18(8):e1010166. doi: 10.1371/journal.pcbi.1010166. eCollection 2022 Aug.
4. Wang J, Van Kranendonk KR, El-Bouri WK, Majoie CBLM, Payne SJ. Mathematical modelling of haemorrhagic transformation within a multiscale microvasculature network. Physiol Meas. 2022 May 31;43(5). doi: 10.1088/1361-6579/ac6cc5.
5. Graff BJ, Payne SJ, El-Bouri WK. The Ageing Brain: Investigating the Role of Age in Changes to the Human Cerebral Microvasculature With an in silico Model. Front Aging Neurosci. 2021 Aug 5;13:632521. doi: 10.3389/fnagi.2021.632521. eCollection 2021.