范碧娟
Pi-Chuan Fan
- 小兒科 專任主治醫師、 臨床副教授
- pcfan6@ntu.edu.tw
- +886-2-2312-3456 ext. 71612
- 分子與細胞神經生物學、生理與系統神經科學、臨床與轉譯神經科學
Lab Introduction & Major Research Interests
For the past 5 years, I have devoted to revealing the age-dependency of migraine and developing new approaches to migraine therapy through both clinical and basic studies.
Clinical research
We found that plasma calcitonin gene related peptide (CGRP) levels are useful for diagnosing and predicting the disability in pediatric migraine. Plasma CGRP may be a potential biomarker in pediatric migraine. We further examined the role of plasma CGRP in patients with new onset migraine after closure of atrial septal defects which revealed bigger ASD size and lower plasma CGRP levels before closure could be a potential predictor of new-onset migraine. Moreover, we found the plasma CGRP level may also serve as a reference for the therapeutic strategy. These results are clinically significant, especially for the young children who cannot clearly describe their headache symptoms.
Basic research
1. Establishing a migraine model in both adolescent and adult rats
2. α6 Subunit-Containing GABAA Receptor (α6GABAARs): A Novel Target for Migraine Therapy
Recent Representative Publication ( * corresponding author)
1. Fan PC, Kuo PH, Chang SH, Lee WT, Wu RM, Chiou LC. Plasma calcitonin gene-related peptide in diagnosing and predicting paediatric migraine. Cephalalgia. 2009;29:883-90.
2. Fan PC, Kuo, P.H., Hu, J.W., Chang, S.H., Hsieh, S.T., Chiou, L.C. Different trigemino-vascular responsiveness between adolescent and adult rats in a migraine model. Cephalalgia. 2012;32:979-90.
3. Wei SH, Fan PC, Kuo PH, Chiou LC, Wang JK. Calcitonin gene-related peptide and size of the atrial septal defect in new-onset migraine after transcatheter closure: results of a preliminary study. Headache. 2012;52:985-92.
4. Fan PC, Lai TH, Hor CC, Lee MT, Huang P, Sieghart W, Ernst M, Knutson DE, Cook J, Chiou LC. The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation. Neuropharmacology. 2018; 140: 1-13.
5. Huang P, Kuo PH, Lee MT, Chiou LC, Fan PC*. Age-dependent anti-migraine effects of valproic acid and topiramate in Rats. Front Pharmacol. 2018; 9:1095. (Corresponding author)
6. Fan PC*, Kuo PH, Lee MT, Chang SH, Chiou LC. Plasma calcitonin gene-related peptide: A potential biomarker for diagnosis and therapeutic responses in pediatric migraine. Front Neurol. 2019; 10:10. (Corresponding author)