Lab Introduction & Major Research Interests
In our laboratory, we use human endothelial cell as model system to investigate the molecular and physiological functions of lysophospholipids, LPA and S1P. Results published by our laboratory and also by others suggested that LPLs might be important regulators of blood vessel formation. In our recent observations, we found that LPLs are potent stimulators for the expression of cell adhesion molecules and chemotatic factors of endothelial cells. Our results suggest that LPL might play important roles in regulating endothelial cell functions. In the future, we will also attempt to investigate the effects of LPLs on other cell systems including cancer cells and neuronal cells.
Recent Representative Publication ( * corresponding author)
1. Chen WM, Chiang JC, Lin YC, Lin YN, Chuang PY, Chang YC, Chen CC, Wu KY, Hsieh JC, Chen SK, Huang WP, Chen BPC* and Lee H*. Lysophosphatidic acid receptor LPA3 prevents oxidative stress and cellular senescence in Hutchinson–Gilford progeria syndrome. Aging Cell. Jan 2020;19(1):e13064.
2. Wu PY, Yu IS, Lin YC, Chang YT, Chen CC, Lin KH, Tseng TH, Kargren M, Tai YL, Shen TL, Liu YL, Wang BJ, Chang CH, Chen WM, Juan HF, Huang SF, Chan YY, Liao YF*, Hsu WM* and Lee H*. Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma. Cancer Res. 79 (21): 5550-5562. Doi: 10.1158/0008-5472.CAN-18-3272. Nov 1st, 2019.
3. Lin YC, Chen CC, Lu KY, Chen WM, Shen TL, Jou YC, Shen CH, Ohbayashi N, Kanaho Y, Huang YL and Lee H*. LPA1/3 signaling mediates tumor lymphangiogenesis through promoting CRT expression in prostate cancer. BBA Molecular and Cell Biology of Lipid. 1863: 1305-1315, 2018.
4. Kuo CT, Lu SR, Chen WM, Wang JY, Lee SC, Chang HH, Wo AM, Chen BPC, Lee H*. Facilitating tumor spheroid-based bioassays and in vitro blood vessel modeling via bioinspired self-formation microstructure devices. Lab on a Chip. 18: 2453-2465. doi: 10.1039/c8lc00423d. [Epub ahead of print July 18, 2018], 2018.