Lab Introduction & Major Research Interests
We are working on the outcomes and mechanisms related to the absorption, distribution, metabolism and excretion of therapeutic agents and toxins. Our current research interests include
(1) Function and regulation of blood-brain barrier under disease states
(2) Roles of membrane transporters in the occurrence and treatment neurodegenerative diseases
(3) Roles of adenosine tone in the treatment of neurodegenerative diseases
Recent Representative Publication ( * corresponding author)
1. Wu KC, Lu YH, Peng YH, Tsai TF, Kao YH, Yang HT, Lin CJ*. Decreased expression of organic cation transporters, Oct1 and Oct2, in brain capillaries and its implication to MPTP-induced dopaminergic toxicity in aged mice. Journal of Cerebral Blood Flow and Metabolism 2015; 35:37–47. (* The corresponding author)
2. Wu KC, Lu YH, Peng YH, Hsu LC, Lin CJ*. Effects of lipopolysaccaride on the expression of plasma membrane monoamine transporter at the blood-brain barrier and its implications to the transport of neurotoxins. Journal of Neurochemistry 2015; 135:1178-1188 (* The corresponding author)
3. Kao YH, Chern Y, Yang HT, Chen HM, Lin CJ*. Regulation of P-glycoprotein expression in brain capillaries of Huntington’s disease transgenic mice and its impact on brain availability of antipsychotic agents risperidone and paliperidone. Journal of Cerebral Blood Flow and Metabolism 2016; 36:1412-1423. (* The corresponding author)
4. Kao YH, Lin MS, Chen CM, Wu YR, Chen HM, Lai HL, Chern Y*, Lin CJ*. Targeting ENT1 and adenosine tone for the treatment of Huntington’s disease. Human Molecular Genetics 2017; 26:467-478.
(* The corresponding author)
5. Wu KC, Liou HH, Kao YH, Lee CY, Lin CJ*. The critical role of Nramp1 in degrading α-synuclein oligomers in microglia under iron overload condition. Neurobiology of Disease, 2017; 104:61–72.
(* The corresponding author)
6. Lin CH, Hsu KW, Chen CH, Uang YS, Lin CJ*. Differential changes in the pharmacokinetics of statins in collagen-induced arthritis rats. Biochemical Pharmacology 2017; 142:216–228. (* The corresponding author)
7. Lee CC, Chang CP, Lin CJ, Lai HL, Kao YH, Cheng SJ, Chen HM, Liao YP, Faivre E, Buée L, Blum D, Fang JM, Chern Y*. (2018) Adenosine augmentation evoked by an ENT1 inhibitor improves memory impairment and neuronal plasticity in the APP/PS1 mouse model of Alzheimer’s disease. Molecular Neurobiology 2018; doi: 10.1007/s12035-018-1030-z.
8. Wu KC, Liou HH, Lee CY, Lin CJ*. Down-regulation of Nramp1 is associated with MPTP/MPP+-induced α-synuclein accumulation and neurotoxicity. Neuropathology and Applied Neurobiology 2019; 45:157-173. (* The corresponding author)
9. Wu KC, Lin CJ*. The regulation of drug-metabolizing enzymes and membrane transporters by inflammation: Evidences in inflammatory diseases and age-related disorders. Journal of Food and Drug Analysis 2019; 27:48-59. (* The corresponding author)
10. Wu KC, Lee CY, Chou FY, Chern Y, Lin CJ*. Deletion of equilibrative nucleoside transporter-2 protects against lipopolysaccharide-induced neuroinflammation and blood-brain barrier dysfunction in mice. Brain Behavior and Immunity 2020; 84:59-71. (The corresponding author)