Lab Introduction & Major Research Interests
My lab is aimed at characterizing how the Ca2+ sensor proteins modulate the synaptic transmission and the roles Zn2+ homeostasis plays in the pathogenesis of neurodegeneration. In addition to the traditional cell biology and electrophysiology approaches, we also applied nanotechnology to study the neurotransmitter release. Recently, we focus on verifying how the interaction among dopamine, Zn2+ homeostasis, and autophagy leads to neuron degeneration and death.
Recent Representative Publication ( * corresponding author)
1. Anand, A., Liu, C.R., Chou, A.-C., Hsu, W.-H., Ulaganathan, R. K., Lin, Y.-C., Dai, C.-A., Tseng, F.-G., Pan, C.-Y.*, and Chen, Y.-T. (2017) Detection of K+ Efflux from Stimulated Cortical Neurons by an Aptamer-Modified Silicon Nanowire Field-Effect Transistor ACS Sens. 2 (1), 69-79. (Corresponding Author)
2. Banerjee, S., Hsieh, Y.-J., Liu, C.-R., Yeh, N-H., Hung, H.-H., Lai, Y.-S., Chou, A.-C., Chen, Y.-T., Pan, C.-Y.* (2016) Differential Releases of Dopamine and Neuropeptide Y from Histamine-Stimulated PC12 Cells Detected by an Aptamer-Modified Nanowire Transistor Small 12 (40), 5524-5529.
3. Chen, K.-I., Pan, C.-Y., Li, K.-H., Huang, Y.-C., Lu, C.-W., Tang, C.-Y., Su, Y.-W., Tseng, L.-W., Tseng, K.-C., Lin, C.-Y., Chen, C.-D., Lin, S.-S., & Chen, Y.-T. (2015) Isolation and Identification of Post-Transcriptional Gene Silencing-Related Micro-RNAs by Functionalized Silicon Nanowire Field-effect Transistor. Sci. Rep. 5, 17375.
4. Chou, A.-C., Ju, Y.-T., and Pan, C.-Y.* (2015) Calmodulin Interacts with the Sodium/Calcium Exchanger NCX1 to Regulate Activity. PLoS ONE 10(9), e0138856.
5. Chou, M.-Y., Lee, C.-Y., Liou, H.-H., and Pan, C.-Y.* (2014) Phenytoin attenuates the hyper-exciting neurotransmission in cultured embryonic cortical neurons. Neuropharmacology 83, 54-61.