Neuroscience Monday 10/30 Lecture – 中心18週年慶系列演講 IV
時間：2023年10月30日（星期一）下午5:30 – 7:00
地點：臺大心理系北館N100階梯教室
講員：陳儀莊特聘研究員/中央研究院生物醫學科學研究所
講題：Microglial Galectin-3 and Neuroinflammation – with A Specific Focus on Neurodegenerative Diseases
摘要：Microglia serve as the brain’s immune guardians. Overactivation of microglia is closely linked to neurodegeneration. Galectin-3 (Gal3), a protein that binds with β-galactoside, has been extensively studied in numerous peripheral system diseases, including lung scarring, various cancers, and heart and kidney failures. Recently, due to its elevated levels in activated microglia, Gal3 has garnered significant attention in the field of neuroscience. In this presentation, we will discuss how human iPSC-derived microglia-like cells respond to exposure to the pathogenic tau protein—a key factor in neurodegeneration—and how they contribute to the spread of this harmful tau protein in the brain via a Gal3-dependent pathway. Considering the connection between microglial activation and various brain disorders, our insights into Gal3’s pathogenic role could deepen our understanding of microglial reactions to misfolded proteins. This knowledge can further guide the development of treatments that target Gal3 in neurodegenerative diseases, such as Huntington’s and Alzheimer’s, which are characterized by the accumulation of misfolded proteins that cause disease and inflammation driven by microglia.
