題目：Sng and Sngception 痠與痠覺
講者：陳志成研究員/中央研究院生物醫學研究所
時間：4/12 (一) 5:30 p.m.
地點：心理系北館演講廳
簡介：日常生活中，常會抱怨說身上這裡或是那裏，覺得痠痠痛痛的！痠跟痛是一樣的嗎？或者只是程度的不同？那要如何來探討這問題呢？若「痠」是一種獨立，像味覺、嗅覺、聽覺等已知的感覺，那就必須證實痠覺有其獨立的神經傳導系統。陳教授的團隊運用各種工具，由受體、離子通道、傳導途徑、大腦感覺區域等，確認相關途徑的存在，從而提出痠覺！
參考資料：
1. 發現新台灣 陳志成教授痠覺理論團隊https://www.youtube.com/watch?v=MzcC6LQnp_s
2. Sensing acidosis: nociception or sngception? https://pubmed.ncbi.nlm.nih.gov/30486810/
3. 演講摘要：
Sng and Sngception
Chih-Cheng Chen
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
“Do you know my sng?” In Chinese society, pain is often described as a compound word “sng-pain” (痠痛), in which sng (pronounced as sә-ng, 痠) is a Taiwanese word that represents the state of feeling sore. However, although chronic sng is a major complaint in many chronic pain diseases and largely affects the quality of life among patients, sng is notoriously ignored in current medicine and is always treated as a mild symptom of pain. In pain clinics, acid or soreness sensation is a characteristic sensory phenotype of various acute and chronic pain syndromes, such as delayed onset muscle soreness, fibromyalgia, and radicular pain. Physiologically, sensing tissue acidosis is an important function of somatosensory nervous system to response to noxious stimuli. However, acid or soreness sensation is also a sign of successful analgesia for acupuncture and many forms of physical therapy. Thus, the nature of acid or soreness sensation is not always nociceptive (or painful) and could be anti-nociceptive. To facilitate the investigation of the molecular and neurobiological mechanisms of soreness sensation, we propose a new concept called “sngception (sng-ception)” to describe the response of the somatosensory nervous system to sense tissue acidosis and to distinguish it from nociception (pain sensation). Sngception could partially overlap with nociception, but it could also transmit antinociception, proprioception, and pruriception. Although proton-sensing ion channels and/or receptors contributing to sngception is not known, candidate membrane proteins include members of acid-sensing ion channels, transient receptor potential channels, proton-sensing G-proton-coupled receptors, and two pore potassium channels. We have thus designed a series of genetic manipulation to explore possible proton-sensing molecules and/or acid-sensitive neurons involved in sngception in mouse models. Moreover, from clinical aspect, we demonstrate sng (soreness) and pain are two distinguishable clinical symptoms with different clinical impacts on patients of chronic low-back pain and fibromyalgia. Together, here we propose sngception as a specific somatosensory function that transmits the acid sensation from the peripheral to the central nervous system.
