講題：Neurological and functional consequences of PTP1B tyrosine phosphatase activation
講員：Prof. Hsiao-Huei Chen (陳曉慧教授) / University of Ottawa, Brain & Mind Institute, Medicine
時間：2023/4/24 (Mon.) 5:30-7:00 PM
地點：臺大心理系北館N100講堂 + Webex 線上同步播放 > 進入線上會議
摘要：
The tyrosine phosphatase PTP1B is an ER-tethered enzyme transiently activated by insulin signaling to terminate the insulin response. However, metabolic stressors can inappropriately and constitutively activate PTP1B with extensive functional consequences. Here, I will give an overview of mechanisms (insulin signaling, endocannabinoid production, presynaptic NMDA receptors) affected by neuron-selective inappropriate activation of PTP1B and its relevance to anxiety, schizophrenia, autism, and Alzheimer’s disease.