賴文崧
Wen-Sung Lai
- 心理學系暨研究所 教授
- wslai@ntu.edu.tw
- Office: 886-2-33663112
- 生理與系統神經科學、神經發育與退化、臨床與轉譯神經科學、認知與社會神經科學
Lab Introduction & Major Research Interests
Our laboratory, Laboratory of Integrated Neuroscience and Ethology (LINE) at NTU, emphasizes the integrative understanding of the links between brain/neurobiology and mental disorders from multi-disciplinary approaches. Our current research interests mainly focus on 4 lines of studies. (1) Basic: To study mouse models of psychiatric disorders and the possible role of AKT1 and other schizophrenia candidate genes in the pathogenesis of schizophrenia. (2) Advance: To investigate higher cognitive functions and reward-based decision making in both mice and schizophrenic patients. (3) Application: Preclinical evaluation of potential drugs for the treatment of schizophrenia. (4) Social: To study social neuroscience and the neural basis of social learning and memory in hamsters, mice, and humans.
Recent Representative Publication ( * corresponding author)
1. Luo, D.Z.#, Chang, C.Y.#, Huang, T.R., Studer, V., Wang, T.W., Lai, W.S.* Lithium for schizophrenia: supporting evidence from a 12-year, nationwide health insurance database and from Akt1-deficient mouse and cellular models. Scientific Reports, 10:647, 2020 (doi: 10.1038/s41598-019-57340-8).
2. Pei, J.C.#, Hung, Wei-Li#, Lin, B.X., Shih, M.H., Lu, L.Y., Luo, D.Z., Tai, H.C., Studer, V., Min, M.Y., Lai, W.S.* Therapeutic potential and underlying mechanism of sarcosine (N-methylglycine) in N-methyl-D-aspartate (NMDA) receptor hypofunction models of schizophrenia. Journal of Psychopharmacology, 33(10), 1288-1302, 2019 (doi: 10.1177/0269881119856558).
3. Liu, H.H.#, Hwang, Y.D., Hsieh, M.H., Hsu, Y.F.*, Lai, W.S.* Misfortune may be a blessing in disguise: Fairness perception and emotion modulate decision making. Psychophysiology, 54(8), 1163-1179, 2017 (doi:10.1111/psyp.12870).
4. Chang, C.Y., Chen, Y.W., Wang, T.W., Lai, W.S.* AKTing up in the GABA hypothesis of schizophrenia: Akt1 deficiency modulates GABAergic functions and hippocampus-dependent functions. Scientific Reports, 6, 33095, 2016 (doi:10.1038/srep33095).
5. Yu, W.C., Liu, C.Y., Lai, W.S.* Repeated, intermittent social defeat across the entire juvenile period resulted in behavioral, physiological, hormonal, immunological, and neurochemical alterations in young adult male golden hamsters. Frontiers in Behavioral Neuroscience, June 10, Volume 10, Article 110, 2016 (doi: 10.3389/fnbeh.2016.00110).
6. Intellectual Property: Patent Cooperation Treaty (PCT) for RS-D7 compound (Publication: WO2015168346A1) and RS-D7 prodrugs/derivatives (Publication: WO/2018/053161)
7. Intellectual Property: USA Patent (NO. 9,868,975; 01/16/2018) for RS-D7 New Indication (Patent title: USE OF KNOWN COMPOUNDS AS D-AMINO ACID OXIDASE INHIBITORS)